accumulate – Communicable Diseases Research

Changes in virus detection in hospitalized children before and after the severe acute respiratory syndrome coronavirus 2 pandemic

중증급성호흡기증후군 코로나바이러스 2 팬데믹 전후 입원 아동의 바이러스 검출 변화

Article

Published on 2022-09-012022-09-11
Journal: Influenza and Other Respiratory Viruses
[Category] COVID19(2023년), SARS, 치료기술,

SARS-CoV-2 vaccination can elicit a CD8 T-cell dominant hepatitis

SARS-CoV-2 예방 접종은 CD8 T 세포 우성 간염을 유발할 수 있습니다

Case Reports

Published on 2022-09-012022-09-12
Journal: Journal of hepatology
[Category] A형 간염, COVID19(2023년), Fulltext, MERS, SARS, 진단,

[키워드] accumulate activated activated T cell antibody Autoimmune Autoimmune hepatitis B cells bimodal BNT162b2 mRNA vaccination CD4 T cells CD8 T cell CD8 T-cell CD8+ CD8+ T cell Cell contribute controls correlated COVID-19 COVID-19 vaccination Cytometry described dissect distribution dominant elicit ELISA feature Flow Hepatitis identify imaging immune immune correlates immune profiling Immune-mediated Immunity immunoglobulins Immunosuppression individual Inflammation intrahepatic Laboratory results liver Liver disease male myeloid cell occur pathophysiology Patient Peripheral blood phenotype Plasma cell presenting reactive SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination severity systemic steroids T cell T cells tissue unique vaccination Virus-specific T cell. was performed
[DOI] 10.1016/j.jhep.2022.03.040 PMC 바로가기 [Article Type] Case Reports

Equine Anti-SARS-CoV-2 Serum (ECIG) Binds to Mutated RBDs and N Proteins of Variants of Concern and Inhibits the Binding of RBDs to ACE-2 Receptor

말 항-SARS-CoV-2 혈청(ECIG)은 돌연변이된 RBD 및 관심 변이의 N 단백질에 결합하고 ACE-2 수용체에 대한 RBD의 결합을 억제합니다

Article

Published on 2022-07-112022-09-11
Journal: Frontiers in Immunology
[Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법,

[키워드] accumulate accumulated mutation accumulated mutations ACE-2 Alpha angiotensin angiotensin-2 converting enzyme anti-SARS-CoV-2 appearance attenuate B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 benefit Beta bind binding caused cell entry concern Course COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients death Delta diagnosed disease domain domains effective ENhance equine equine serum experiment Gamma generate greater Host host cell Immunoglobulin infect Infection interact lethality limit mutated Mutation mutations Neutralizing Neutralizing activity Neutralizing antibodies notable nucleocapsid nucleocapsid protein Nucleocapsid proteins nucleocapsid. omicron Prevent RBD RBD region receptor Recombination reduce reducing reported SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 virus Spike protein SPR Spread surface plasmon surface plasmon resonance syndrome the disease the spike protein therapy variant variants Viral viral entry virus VoC VOCs VOI VOIs wild-type
[DOI] 10.3389/fimmu.2022.871874 PMC 바로가기 [Article Type] Article

Host chitinase 3-like-1 is a universal therapeutic target for SARS-CoV-2 viral variants in COVID-19

숙주 키티나제 3-유사-1은 COVID-19의 SARS-CoV-2 바이러스 변이체에 대한 보편적인 치료 표적입니다

Article

Published on 2022-06-232022-09-11
Journal: eLife
[Category] COVID19(2023년), SARS, 변종,

[키워드] accumulate ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Alpha anti-CHI3L1 antibody Antibody neutralization Beta breakthrough infections caused Cell CHI3L1 chitinase Concentration coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 defined Delta delta variant demonstrated determine effective inhibitor epithelial epithelial cell Express FRG genetic variability host tissue induce Infection Infectious disease inhibit inhibitor Intervention kasugamycin Laboratory lethal disease Microbiology morbidity and mortality neutralization omicron priming protease pseudovirus pseudovirus pseudoviruses S protein SARS-CoV-2 viral Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe disease spike stimulate strain susceptibility the disease therapeutic target Therapeutics Transmissibility variant variants variants of concern viral variant viruses viruses. VoC Waves worldwide pandemic
[DOI] 10.7554/eLife.78273 PMC 바로가기 [Article Type] Article

SARS-CoV-2 Continuous Genetic Divergence and Changes in Multiplex RT-PCR Detection Pattern on Positive Retesting Median 150 Days after Initial Infection

SARS-CoV-2 지속적인 유전적 분화 및 초기 감염 후 150일의 양성 재검사 중앙값에 대한 다중 RT-PCR 검출 패턴의 변화

Article

Published on 2022-06-022022-09-11
Journal: International Journal of Molecular Sciences
[Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료법, 치료제,

[키워드] accumulate amplification Amplification assay analyzed being Chain Reaction change Clinical diagnosis Continuous COVID-19 COVID-19 pandemic Day detection diagnostic Divergence envelope gene epicenter Epidemiology evaluated Evolution Frequency gene amplification Genetic genetic divergence genomes highlight hotspot identify in viral independent Infection initial isolate isolates lab molecular molecular evolution multiplex Multiplex RT-PCR Mutation next generation sequencing NGS Nucleocapsid gene Patient pattern performed polymerase chain polymerase chain reaction positive primer probe Region Reinfection reverse transcription reverse transcription polymerase chain reaction RT-PCR SARS-CoV-2 SARS-CoV-2 RNA specimen Spectrum target tested utility Viral viral genome viral genomes Viral variants Viral variants. virus WGA whole genome
[DOI] 10.3390/ijms23116254 PMC 바로가기 [Article Type] Article

Isothermal amplification-assisted diagnostics for COVID-19

COVID-19에 대한 등온 증폭 지원 진단

Review

Published on 2022-06-012022-09-11
Journal: Biosensors & bioelectronics
[Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술,

Lung targeted liposomes for treating ARDS

ARDS 치료를 위한 폐 표적 리포솜

Article

Published on 2022-06-012022-09-11
Journal: Journal of controlled release : official journal o
[Category] 치료제,

[키워드] accumulate accumulation acute respiratory distress acute respiratory distress syndrome Administered administration alveolar approach ARDS BAL Bronchoalveolar lavage C57BL/6 characterized combined treatment COPD COVID-19 COVID-19 infections cysteine cytokine secretion distal DPPC drug Efficiency encapsulation endotracheal exhibited Gas exchange Hypoxemia IL-1β IL-6 impair infections Inflammation Inflammatory marker inflammatory markers intravenous intravenously lipid composition Lipid nanoparticles lipopolysaccharide Liposome lung lung damage Lung diseases lung disorders lung endothelial lung epithelial Lung inflammation Lungs Macrophage macrophages marker medication Methylprednisolone mice mortality rate mortality rates MPS mucolytic agent Mucus N-acetyl cysteine NAC nanoparticle Nanotechnology nitric oxide outcome Patient penetration provided pulmonary Pulmonary. reached reduce reducing Region respiratory respiratory distress Respiratory distress syndrome secretion steroid syndrome therapeutic therapeutic effect therapeutic efficacy TNFα Treatment Treatment outcome were assessed
[DOI] 10.1016/j.jconrel.2022.03.028 PMC 바로가기 [Article Type] Article

Transcriptomic perspectives of memory-like NK cells and aging

기억 유사 NK 세포와 노화의 전사적 관점

Article

Published on 2022-05-252022-09-11
Journal: Genome Medicine
[Category] 유전자 메커니즘,

Single-cell transcriptomics reveal a unique memory-like NK cell subset that accumulates with ageing and correlates with disease severity in COVID-19

단일 세포 전사체는 노화와 함께 축적되고 COVID-19의 질병 중증도와 상관관계가 있는 고유한 기억 유사 NK 세포 하위 집합을 나타냅니다.

Article

Published on 2022-05-032022-09-11
Journal: Genome Medicine
[Category] Coronavirus, 유전자 메커니즘, 치료제,

[키워드] accumulate accumulated age Ageing analysed analysis antiviral responses applied CD52 Cell Characteristics COVID-19 COVID-19 disease COVID-19 patient dataset disease severity distribution dysfunction exhibited exhibiting flow cytometry function healthy control healthy donor healthy donors identify IFN-α immune system immunotherapies Immunotherapy Impact in vitro individual Infectious disease Infectious diseases influence innate lymphoid cell Innate lymphoid cells interferon lymphocyte Lymphocytes natural NK cell NK cells Peripheral blood peripheral blood samples phenotype positively correlated proinflammatory proportion scRNA-seq Sequencing Seurat single-cell single-cell level single-cell RNA-seq single-cell transcriptome single-cell transcriptomes Single-cell transcriptomics subpopulation subset Transcriptome type I interferon Type-I interferon. unique
[DOI] 10.1186/s13073-022-01049-3 PMC 바로가기 [Article Type] Article

Analysis of clinical characteristics of 66 pediatric patients with B.1.617.2 (Delta) variant of COVID-19

COVID-19의 B.1.617.2(델타) 변이형 소아 환자 66명의 임상적 특성 분석

Article

Published on 2022-05-012022-09-11
Journal: World Journal of Pediatrics
[Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법,

[키워드] 24 hour 24 hours accumulate acute respiratory syndrome acute respiratory syndrome coronavirus Admission age All the patient all the patients Analysis analyzed antibody B.1.617.2 B.1.617.2 (Delta) cardiac troponin Cardiac troponin I Characteristics children children with COVID-19 clinical Clinical characteristics clinical experience Clinical features clinical symptom Clinical symptoms Cluster coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19). COVID-19 Cycle threshold value Cycle threshold values D-dimer Delta description disease onset erythrocyte sedimentation erythrocyte sedimentation rate evaluate Frame Gender Genome gradually increased group help hospital IgG IgM IgM antibodies IgM antibody Immunoglobulin Incubation period laboratory data medical staff Mild moderate nucleocapsid protein Open reading frame open reading frame 1 Pediatric patient positive respiratory sedimentation rate severe acute respiratory syndrome Coronavirus statistically significant difference Symptom tested titers troponin I variant
[DOI] 10.1007/s12519-022-00529-1 PMC 바로가기 [Article Type] Article